APC Anti-Human CD273/PD-L2 Antibody[24F.10C12]
Product Specifications
Background
CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2) . This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.
Abbreviation
CD273
Gene ID
80380
UniProt
Q9BQ51
Host
Mouse
Reactivity
Human
Target
CD273PDCD1L2PDL2; B7DC
Clonality
Monoclonal
Clone
24F.10C12
Conjugation
APC
Applications
FCM
Field of Research
Costimulatory Molecules; Immunology
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://www.sciencedirect.com/science/article/pii/S2211124719314159
Citation 02
https://www.nature.com/articles/s41389-023-00500-3
Citation 03
https://www.mdpi.com/2073-4425/14/8/1620
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG2a, κ
Available Sizes
Curated Selection
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