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FITC Anti-Human CD45 Antibody[HI30]

Product Specifications

Background

CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Abbreviation

CD45

Gene ID

5788

UniProt

P08575

Host

Mouse

Reactivity

Human

Target

CD45; L-CA; Ly-5; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200

Clonality

Monoclonal

Clone

HI30

Conjugation

FITC

Applications

FCM

Field of Research

Cell Biology; Immunology; Inhibitory Molecules; Innate Immunity; Neuroscience; Neuroscience Cell Markers; Stem Cells

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Product Datasheet

https://789.bio/ea/cgqp4g

Product MSDS

https://789.bio/eb/GerzTG

Citation 01

https://www.nature.com/articles/s41467-025-60448-3

Citation 02

https://www.nature.com/articles/s41467-025-58301-8

Citation 03

https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202500614

Citation 04

https://jbioleng.biomedcentral.com/articles/10.1186/s13036-025-00524-w

Citation 05

https://www.frontiersin.org/articles/10.3389/fbioe.2021.707208/full

Citation 06

https://link.springer.com/article/10.1007/s13577-023-00918-2

Citation 07

https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1489774/full

Citation 08

https://link.springer.com/article/10.1007/s13770-024-00642-4

Citation 09

https://www.sciencedirect.com/science/article/pii/S0026265X24026833

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Mouse IgG1, κ

Available Sizes

Curated Selection

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