APC Anti-Mouse CD45 Antibody[30-F11]

Product Specifications

Background

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from alternative splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Abbreviation

CD45

Gene ID

19264

UniProt

P06800

Host

Rat

Reactivity

Mouse

Target

CD45; L-CA; Ly-5; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200

Clonality

Monoclonal

Clone

30-F11

Conjugation

APC

Applications

FCM

Field of Research

Cell Biology; Immunology; Inhibitory Molecules; Innate Immunity; Neuroscience; Neuroscience Cell Markers; Stem Cells

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.sciencedirect.com/science/article/pii/S0142961225000158

Citation 02

https://www.nature.com/articles/s41419-019-1796-6

Citation 03

https://www.sciencedirect.com/science/article/pii/S1567576923001625

Citation 04

https://www.sciencedirect.com/science/article/pii/S0024320525003480

Citation 05

https://www.sciencedirect.com/science/article/pii/S0006295225003181

Citation 06

https://www.sciencedirect.com/science/article/pii/S0898656823001821

Citation 07

https://www.sciencedirect.com/science/article/pii/S1567576924012177

Citation 08

https://peerj.com/articles/13082/

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2b, κ

Available Sizes

Documents

Product Datasheet

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