FITC Anti-Mouse CD45 Antibody[30-F11]

Product Specifications

Background

CD45 is a 180-240 kD glycoprotein also known as the leukocyte common antigen (LCA), T200, or Ly-5. It is a member of the protein tyrosine phosphatase (PTP) family, expressed on all hematopoietic cells except mature erythrocytes and platelets. There are different isoforms of CD45 that arise from alternative splicing of exons 4, 5, and 6, which encode A, B, and C determinants, respectively. CD45 plays a key role in TCR and BCR signal transduction. These isoforms are very specific to the activation and maturation state of the cell as well as cell type. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4, TCR, CD22, and Thy-1.

Abbreviation

CD45

Gene ID

19264

UniProt

P06800

Host

Rat

Reactivity

Mouse

Target

CD45; L-CA; Ly-5; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200

Clonality

Monoclonal

Clone

30-F11

Conjugation

FITC

Applications

FCM

Field of Research

Cell Biology; Immunology; Inhibitory Molecules; Innate Immunity; Neuroscience; Neuroscience Cell Markers; Stem Cells

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.nature.com/articles/s41590-022-01166-6

Citation 02

https://www.nature.com/articles/s41551-021-00774-1

Citation 03

https://www.sciencedirect.com/science/article/pii/S1385894724065392

Citation 04

https://www.sciencedirect.com/science/article/pii/S0168365925001749

Citation 05

https://www.sciencedirect.com/science/article/pii/S0304383524005007

Citation 06

https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(25)00161-4

Citation 07

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.5c01821

Citation 08

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202200408R

Citation 09

https://www.sciencedirect.com/science/article/pii/S0014299923005496

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2b, κ

Available Sizes

Documents

Product Datasheet

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