APC Anti-Mouse CD206/MMR Antibody[C068C2]

Product Specifications

Background

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

Abbreviation

CD206

Gene ID

17533

UniProt

Q61830

Host

Rat

Reactivity

Mouse

Target

MMR; MR; MRC1; macrophage mannose receptor; mannose receptor

Clonality

Monoclonal

Clone

C068C2

Conjugation

APC

Applications

FCM; ICFCM

Field of Research

Cell Biology; Immunology; Innate Immunity; Signal Transduction

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202212870

Citation 02

https://pubs.acs.org/doi/abs/10.1021/acsnano.3c09140

Citation 03

https://pubs.acs.org/doi/abs/10.1021/acsnano.3c04189

Citation 04

https://www.sciencedirect.com/science/article/pii/S1385894723070006

Citation 05

https://www.sciencedirect.com/science/article/pii/S1385894723063775

Citation 06

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c03669

Citation 07

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c15201

Citation 08

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c12131

Citation 09

https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202310163

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ

Available Sizes

Documents

Product Datasheet

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