DBCO-mPEG (MW 5kDa)
DBCO-mPEG (MW 5kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-mPEG (MW 5kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352005
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-mpeg-mw-5kda.html
Purity
98.41
Solubility
DMF : ≥ 100 mg/mL|DMSO : ≥ 100 mg/mL
Smiles
O=C(CCC(NCCOCCOC)=O)N1CC2=CC=CC=C2C#CC3=C1C=CC=C3.[n].[MW5kDa]
Molecular Weight
5000 (Average)
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
Curated Selection
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