FITC Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]

Product Specifications

Background

CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.

Abbreviation

CD274

Gene ID

60533

UniProt

Q9EP73

Host

Rat

Reactivity

Mouse

Target

B7H1PD-L1PDCD1L1PDCD1LG1PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1

Clonality

Monoclonal

Clone

10F.9G2

Conjugation

FITC

Applications

FCM

Field of Research

Cancer Biomarkers; Costimulatory Molecules; Immunology

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.nature.com/articles/s41467-024-53010-0

Citation 02

https://www.sciencedirect.com/science/article/pii/S016836592400124X

Citation 03

https://journals.aai.org/jimmunol/article/doi/10.4049/jimmunol.2300718/266932

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2b, κ

Available Sizes

Documents

Product Datasheet

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