Purified Anti-Mouse CD274/PD-L1 Antibody[10F.9G2]
Product Specifications
Background
CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Abbreviation
CD274/PD-L1
Gene ID
60533
UniProt
Q9EP73
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant Mouse CD274 protein
Target
B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; B7 homolog 1; B7-H; B7-H1; Programmed cell death ligand 1
Clonality
Monoclonal
Clone
10F.9G2
Conjugation
Unconjugated
Applications
FCM
Field of Research
Cancer Biomarkers; Costimulatory Molecules; Immunology
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/vjnb5o
Product MSDS
https://789.bio/eb/Wvfbj5
Citation 01
https://www.nature.com/articles/s41598-024-51361-8
Recommended Usage
6
Isotype
Rat IgG2b, κ
Available Sizes
Curated Selection
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