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PE Anti-Mouse CD279/PD-1 Antibody[29F.1A12]

Product Specifications

Background

CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Abbreviation

CD279

Gene ID

18566

UniProt

Q02242

Host

Rat

Reactivity

Mouse

Target

Programmed Death-1; PD-1

Clonality

Monoclonal

Clone

29F.1A12

Conjugation

PE

Applications

FCM

Field of Research

Cancer Biomarkers; Immunology; Inhibitory Molecules

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Product Datasheet

https://789.bio/ea/xtm9q5

Product MSDS

https://789.bio/eb/8GOSCS

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202301019

Citation 02

https://www.sciencedirect.com/science/article/pii/S075333222400920X

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ

Available Sizes

Curated Selection

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