PE Anti-Mouse CD279/PD-1 Antibody[29F.1A12]
Product Specifications
Background
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2) . It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
Abbreviation
CD279
Gene ID
18566
UniProt
Q02242
Host
Rat
Reactivity
Mouse
Target
Programmed Death-1; PD-1
Clonality
Monoclonal
Clone
29F.1A12
Conjugation
PE
Applications
FCM
Field of Research
Cancer Biomarkers; Immunology; Inhibitory Molecules
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202301019
Citation 02
https://www.sciencedirect.com/science/article/pii/S075333222400920X
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Rat IgG2a, κ
Available Sizes
Documents
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