LP-533401 hydrochloride
LP-533401 hydrochloride is a tryptophan hydroxylase 1 inhibitor that regulates serotonin production in the gut.
Product Specifications
CAS Number
1040526-12-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/LP-533401_hydrochloride.html
Purity
99.36
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
N[C@@H](CC1=CC=C(C2=NC(N)=NC(OC(C3=CC=C(C4=CC=CC(F)=C4)C=C3)C(F)(F)F)=C2)C=C1)C(O)=O.[H]Cl
Molecular Formula
C27H23ClF4N4O3
Molecular Weight
562.94
Precautions
H302, H315, H319, H335
References & Citations
[1]Yadav, V.K., et al. Inhibition of gut-derived serotonin synthesis: A potential bone anabolic treatment. Nat. Med. 16 (3), 308-312 (2010) .|[2]Abid S, et al. Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303 (6) :L500-8.|[3]Krevvata M, et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood. 2014 Oct 30;124 (18) :2834-46.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Nat Aging. 2024 Feb 6.|Nat Aging. 2024 Mar;4 (3) :414-433.|Cell Signal. 2023 May:105:110612.|iMetaOmics. 2024 Oct 14.|iScience. 2025 Nov 18.|Life Sci. 2021 Nov 15:285:120002.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740226-100 1x 100 µL
Pmel17 / gp100 / SILV (NKI-beteb), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041081-100 1x 100 µL
CD45RO (190-2F2.5), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881429-100 1x 100 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470043-500 1x 500 µL
P21 / WAF1 (WA-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details