APC Anti-Mouse CD49b/pan-NK cells Antibody[DX5]

Product Specifications

Background

DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection) . DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

Abbreviation

CD49b

Gene ID

16398

UniProt

Q62469

Host

Rat

Reactivity

Mouse

Target

CD49 antigen-like family member B; CD49b; Collagen receptor; GPIa; Integrin alpha-2; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha; pan-NK cells

Clonality

Monoclonal

Clone

DX5

Conjugation

APC

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Innate Immunity

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.sciencedirect.com/science/article/pii/S0753332224015543

Citation 02

https://www.sciencedirect.com/science/article/pii/S0378517324009931

Citation 03

https://www.sciencedirect.com/science/article/pii/S1756464624000197

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgM, κ

Available Sizes

Documents

Product Datasheet

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