AF/LE Purified Anti-Mouse CD18 Antibody[M18/2]

Product Specifications

Background

CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.

Abbreviation

CD18

Gene ID

16414

UniProt

P11835

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD18 protein

Target

Integrin beta; ITGB; CD18; Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta; Complement receptor C3 subunit beta; Integrin beta-2; Itgb2; &beta-2 integrin-n

Clonality

Monoclonal

Clone

M18/2

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Innate Immunity

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.