AF/LE Purified Anti-Mouse CD18 Antibody[M18/2]
Product Specifications
Background
CD18 is a 95 kD protein, also known as integrin β2 subunit. It is expressed on all leukocytes. CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and αXβ2, respectively, and plays an important role in leukocytes adhesion. The CD18 integrin complexes bind ICAM-1 (CD54), ICAM-2 (CD102), ICAM-3 (CD50), iC3b, and fibrinogen. The M18/2 antibody is able to block tumor cell metastasis and enhance cell adhesion.
Abbreviation
CD18
Gene ID
16414
UniProt
P11835
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant Mouse CD18 protein
Target
Integrin beta; ITGB; CD18; Cell surface adhesion glycoproteins LFA-1/CR3/p150+95 subunit beta; Complement receptor C3 subunit beta; Integrin beta-2; Itgb2; &beta-2 integrin-n
Clonality
Monoclonal
Clone
M18/2
Conjugation
None (AF/LE)
Applications
FCM
Field of Research
Cell Adhesion; Cell Biology; Immunology; Innate Immunity
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Recommended Usage
6
Isotype
Rat IgG2a, κ
Available Sizes
Documents
Frequently Asked Questions
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