APC Anti-Mouse CD115/CSF-1R Antibody[AFS98]
Product Specifications
Background
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Abbreviation
CD115
Gene ID
12978
UniProt
P09581
Host
Rat
Reactivity
Mouse
Target
CD115; CSF-1 receptor (EC:2.7.10.1) ; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fms; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms
Clonality
Monoclonal
Clone
AFS98
Conjugation
APC
Applications
FCM
Field of Research
Immunology
Concentration
0.2 mg/mL
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Product Datasheet
https://789.bio/ea/9omdet
Product MSDS
https://789.bio/eb/yfbbf5
Recommended Usage
6
Isotype
Rat IgG2a, κ
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
