Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98]
Product Specifications
Background
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Abbreviation
CD115
Gene ID
12978
UniProt
P09581
Host
Rat
Reactivity
Mouse
Immunogen
Recombinant Mouse CD115 protein
Target
CD115; CSF-1 receptor (EC:2.7.10.1) ; CSF-1-R; CSF-1R; Csf1r; Csfmr; Fms; M-CSF-R; Macrophage colony-stimulating factor 1 receptor; Proto-oncogene c-Fms
Clonality
Monoclonal
Clone
AFS98
Conjugation
Unconjugated
Applications
FCM
Field of Research
Immunology
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
PBS, pH 7.2. Contains 0.05% proclin 300.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/ckabvh
Product MSDS
https://789.bio/eb/fXz9CC
Recommended Usage
6
Isotype
Rat IgG2a, κ
Available Sizes
Curated Selection
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