PE Anti-Mouse CD8a Antibody[53-6.7]

Product Specifications

Background

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Abbreviation

CD8a

Gene ID

12525

UniProt

P01731

Host

Rat

Reactivity

Mouse

Target

CD8A; MAL; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2

Clonality

Monoclonal

Clone

53-6.7

Conjugation

Applications

FCM

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c11412

Citation 02

https://www.sciencedirect.com/science/article/pii/S1385894723044376

Citation 03

https://www.sciencedirect.com/science/article/pii/S138589472307002X

Citation 04

https://www.sciencedirect.com/science/article/pii/S0142961223001552

Citation 05

https://www.sciencedirect.com/science/article/pii/S1385894725002256

Citation 06

https://www.sciencedirect.com/science/article/pii/S1385894724039548

Citation 07

https://www.sciencedirect.com/science/article/pii/S0142961225000158

Citation 08

https://www.tandfonline.com/doi/abs/10.1080/19490976.2024.2442037

Citation 09

https://jeccr.biomedcentral.com/articles/10.1186/s13046-022-02564-2

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ

Available Sizes

Documents

Product Datasheet

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