Purified Anti-Human/Mouse CD44 Antibody[IM7]

Product Specifications

Background

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Abbreviation

CD44

Gene ID

12505;960

UniProt

P15379; P16070

Host

Rat

Reactivity

Human; Mouse

Immunogen

Recombinant Human; Mouse CD44 protein

Target

MDU2; MDU3; MIC4; CD44; CD44 antigen; CDw44; Epican; LHR; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I

Clonality

Monoclonal

Clone

IM7

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cell Adhesion; Cell Biology; Immunology; Stem Cells

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Citation 01

https://www.sciencedirect.com/science/article/pii/S2211383525002382

Citation 02

https://www.sciencedirect.com/science/article/pii/S0168365925004092

Citation 03

https://www.sciencedirect.com/science/article/pii/S1742706125000467

Citation 04

https://www.tandfonline.com/doi/abs/10.2147/IJN.S441133

Citation 05

https://www.tandfonline.com/doi/abs/10.2147/DDDT.S482969

Recommended Usage

Isotype

Rat IgG2b, κ

Available Sizes

Documents

Product Datasheet

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