Purified Anti-Human CD32 Antibody[IV-3]
Product Specifications
Background
CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform) .
Abbreviation
CD32
Gene ID
2213
UniProt
P31994
Host
Mouse
Reactivity
Human
Immunogen
Recombinant Human CD32 protein
Target
IGFR2; CD32; CDw32; FCG2; FCGR2B; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; IgG Fc receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-b
Clonality
Monoclonal
Clone
IV-3
Conjugation
Unconjugated
Applications
FCM; Block
Field of Research
Immunology; Innate Immunity
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Recommended Usage
6
Isotype
Mouse IgG2b, κ
Available Sizes
Documents
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