Purified Anti-Human CD35 Antibody[E11]
Product Specifications
Background
CD35, also known as complement receptor 1 (CR1), is a 220-300 kDa N-glycosylated member of the RCA (regulators of complement activation) family of proteins. CD35 binds and internalizes particles and immune complexes that are opsonized with MBL or complement components C3b, C3i, C4b, or C1q. CD35 additionally protects the cell from complement-mediated lysis by serving as a cofactor for Factor I and inhibiting the C3 and C5 convertases. The extracellular domain (ECD) of human CD35 contains 30 tandem SCR/SUSHI repeats.
Abbreviation
CD35
Gene ID
1378
UniProt
P17927
Host
Mouse
Reactivity
Human
Immunogen
Recombinant Human CD35 protein
Target
C3BR; C3b/C4b receptor; CD35; CR1; Complement receptor type 1
Clonality
Monoclonal
Clone
E11
Conjugation
Unconjugated
Applications
FCM
Field of Research
Cell Biology; Complement; Immunology; Neuroinflammation; Neuroscience
Purification
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
PBS, pH 7.2. Contains 0.05% proclin 300.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Recommended Usage
6
Isotype
Mouse IgG1, κ
Available Sizes
Documents
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