Purified Anti-Human CD35 Antibody[E11]

Product Specifications

Background

CD35, also known as complement receptor 1 (CR1), is a 220-300 kDa N-glycosylated member of the RCA (regulators of complement activation) family of proteins. CD35 binds and internalizes particles and immune complexes that are opsonized with MBL or complement components C3b, C3i, C4b, or C1q. CD35 additionally protects the cell from complement-mediated lysis by serving as a cofactor for Factor I and inhibiting the C3 and C5 convertases. The extracellular domain (ECD) of human CD35 contains 30 tandem SCR/SUSHI repeats.

Abbreviation

CD35

Gene ID

1378

UniProt

P17927

Host

Mouse

Reactivity

Human

Immunogen

Recombinant Human CD35 protein

Target

C3BR; C3b/C4b receptor; CD35; CR1; Complement receptor type 1

Clonality

Monoclonal

Clone

E11

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cell Biology; Complement; Immunology; Neuroinflammation; Neuroscience

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

PBS, pH 7.2. Contains 0.05% proclin 300.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Recommended Usage

Isotype

Mouse IgG1, κ

Available Sizes

Documents

Product Datasheet

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