Purified Anti-Human CD62L Antibody[DREG56]
Product Specifications
Background
CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naive T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naive, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.
Abbreviation
CD62L
Gene ID
6402
UniProt
P14151
Host
Mouse
Reactivity
Human
Target
CD62L; CD62 antigen-like family member L; L-selectin; LAM-1; LECAM1; Lnhr; Ly-22; Ly22; Lymph node homing receptor; Sell
Clonality
Monoclonal
Clone
DREG56
Conjugation
Unconjugated
Applications
FCM
Field of Research
Cell Adhesion; Cell Biology; Costimulatory Molecules; Immunology; Innate Immunity
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Recommended Usage
6
Isotype
Mouse IgG1, κ
Available Sizes
Documents
Curated Selection
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