PE Anti-Human CD40 Antibody[3A8]
Product Specifications
Background
CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand) . The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
Abbreviation
CD40
Gene ID
958
UniProt
P25942
Host
Mouse
Reactivity
Human
Target
B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; Cd40; Tnfrsf5; Tumor necrosis factor receptor superfamily member 5
Clonality
Monoclonal
Clone
3A8
Conjugation
PE
Applications
FCM
Field of Research
Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers
Concentration
5 μL/Test
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Citation 01
https://www.sciencedirect.com/science/article/pii/S1567576925006551
Recommended Usage
The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .
Isotype
Mouse IgG2a, κ
Available Sizes
Documents
Frequently Asked Questions
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