Purified Anti-Mouse CD120b/TNFR2 Antibody[TR75-54.7]

CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β) . In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

CD120b; TNF-R2; TNF-RII; TNFR-II; Tnfrsf1b; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; p75; p80 TNF-alpha receptor