APC Anti-Mouse CD40 Antibody[FGK4.5/FGK45]

Product Specifications

Background

CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

Abbreviation

CD40

Gene ID

21939

UniProt

P27512

Host

Rat

Reactivity

Mouse

Target

B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; Cd40; Tnfrsf5; Tumor necrosis factor receptor superfamily member 5

Clonality

Monoclonal

Clone

FGK4.5/FGK45

Conjugation

APC

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://www.nature.com/articles/s41467-025-60448-3

Citation 02

https://www.sciencedirect.com/science/article/pii/S0141813024067230

Citation 03

https://www.sciencedirect.com/science/article/pii/S0141813024038728

Citation 04

https://www.sciencedirect.com/science/article/pii/S1567576923008135

Citation 05

https://www.mdpi.com/1660-3397/20/3/197

Citation 06

https://www.mdpi.com/1422-0067/25/14/7765

Citation 07

https://www.tandfonline.com/doi/abs/10.1080/09540105.2020.1743647

Citation 08

https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-020-03031-1

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ

Available Sizes

Documents

Product Datasheet

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