AF/LE Purified Anti-Mouse CD40 Antibody[FGK4.5/FGK45]

Product Specifications

Background

CD40 is a 48 kD type I transmembrane glycoprotein also known as Bp50. It is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on B cells, basal epithelial cells, macrophages, follicular dendritic cells, endothelial cells, and a subset of CD34+ hematopoietic progenitors. CD40 regulates B cell development/maturation, Ig isotype switching and, in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with its ligand CD154 (gp39), which is expressed on activated T cells, is important in costimulation and immune regulation.

Abbreviation

CD40

Gene ID

21939

UniProt

P27512

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse CD40 protein

Target

B-cell surface antigen CD40; Bp50; CD40; CD40L receptor; Cd40; Tnfrsf5; Tumor necrosis factor receptor superfamily member 5

Clonality

Monoclonal

Clone

FGK4.5/FGK45

Conjugation

None (AF/LE)

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.