Purified Anti-Mouse CD132 Antibody[3E12]

CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID) .

CD132; Cytokine receptor common subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; Il2rg; Interleukin-2 receptor subunit gamma; gammaC; p64