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Purified Anti-Human CD86 Antibody[BU63]

Product Specifications

Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD86

Gene ID

942

UniProt

P42081

Host

Mouse

Reactivity

Human

Target

Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

Clonality

Monoclonal

Clone

BU63

Conjugation

Unconjugated

Applications

FCM; Block

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/fl4kco

Product MSDS

https://789.bio/eb/rLGKqD

Citation 01

https://link.springer.com/article/10.1186/s12967-024-04931-3

Citation 02

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020012/

Recommended Usage

6

Isotype

Mouse IgG1, κ

Available Sizes

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