Purified Anti-Human CD86 Antibody[BU63]
Product Specifications
Background
CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is the ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce costimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can bind to CD152 as well, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Abbreviation
CD86
Gene ID
942
UniProt
P42081
Host
Mouse
Reactivity
Human
Target
Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86
Clonality
Monoclonal
Clone
BU63
Conjugation
Unconjugated
Applications
FCM; Block
Field of Research
Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Citation 01
https://link.springer.com/article/10.1186/s12967-024-04931-3
Citation 02
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020012/
Recommended Usage
6
Isotype
Mouse IgG1, κ
Available Sizes
Documents
Curated Selection
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