Purified Anti-Mouse F4/80 Antibody[CI:A3-1]

Product Specifications

Background

F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF) -transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

Abbreviation

F4/80

Gene ID

13733

UniProt

Q61549

Host

Rat

Reactivity

Mouse

Immunogen

Recombinant Mouse F4/80 protein

Target

Gpf480; Adgre1; Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module receptor 1; Emr1

Clonality

Monoclonal

Clone

CI:A3-1

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cell Biology; Immunology; Innate Immunity; Neuroinflammation; Neuroscience

Purification

>98%, Protein A/G purified

Concentration

≥ 1 mg/mL

Dilution

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Citation 01

https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/advs.202414548

Citation 02

https://www.nature.com/articles/s12276-025-01465-6

Citation 03

https://www.cell.com/developmental-cell/abstract/S1534-5807(24)00329-0

Citation 04

https://www.sciencedirect.com/science/article/pii/S0144861722009523

Citation 05

https://www.sciencedirect.com/science/article/pii/S1742706125000467

Citation 06

https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202201708RR

Citation 07

https://www.cell.com/heliyon/fulltext/S2405-8440(24)13033-2

Citation 08

https://www.tandfonline.com/doi/abs/10.1080/10826068.2024.2444979

Recommended Usage

Isotype

Rat IgG2b, κ

Available Sizes

Documents

Product Datasheet

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