APC Anti-Mouse CD86 Antibody[GL-1]

Product Specifications

Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD86

Gene ID

12524

UniProt

P42082

Host

Rat

Reactivity

Mouse

Target

Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

Clonality

Monoclonal

Clone

GL-1

Conjugation

APC

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

0.2 mg/mL

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Citation 01

https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202301561

Citation 02

https://www.nature.com/articles/s41401-024-01333-5

Citation 03

https://www.mdpi.com/2218-273X/10/1/159

Citation 04

https://www.mdpi.com/1660-3397/20/3/197

Citation 05

https://www.mdpi.com/2218-273x/10/1/159

Recommended Usage

Isotype

Rat IgG2a, κ

Available Sizes

Documents

Product Datasheet

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