APC Anti-Mouse CD86 Antibody[GL-1]

Product Specifications

Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD86

Gene ID

12524

UniProt

P42082

Host

Rat

Reactivity

Mouse

Target

Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

Clonality

Monoclonal

Clone

GL-1

Conjugation

APC

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

5 μL/Test

Buffer

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Shipping Conditions

Ice bag

Storage Conditions

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Product Datasheet

https://789.bio/ea/qnzt8s

Product MSDS

https://789.bio/eb/OOWvTG

Citation 01

https://www.sciencedirect.com/science/article/pii/S1748013223002864

Citation 02

https://pubs.acs.org/doi/abs/10.1021/acsnano.3c04189

Citation 03

https://www.nature.com/articles/s41467-023-40826-5

Citation 04

https://www.sciencedirect.com/science/article/pii/S1385894723052051

Citation 05

https://www.sciencedirect.com/science/article/pii/S138589472307002X

Citation 06

https://www.sciencedirect.com/science/article/pii/S1385894723063775

Citation 07

https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202207490

Citation 08

https://pubs.acs.org/doi/abs/10.1021/acsnano.3c11848

Citation 09

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c07213

Recommended Usage

The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood) .

Isotype

Rat IgG2a, κ

Available Sizes

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