Biotin Anti-Mouse CD86 Antibody[GL-1]
Product Specifications
Background
CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.
Abbreviation
CD86
Gene ID
12524
UniProt
P42082
Host
Rat
Reactivity
Mouse
Target
Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86
Clonality
Monoclonal
Clone
GL-1
Conjugation
Biotin
Applications
FCM
Field of Research
Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers
Concentration
0.5 mg/mL
Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
This product can be stored at 2-8°C for 12 months. Do not freeze.
Recommended Usage
6
Isotype
Rat IgG2a, κ
Available Sizes
Documents
Curated Selection
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