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Purified Anti-Mouse CD86 Antibody[GL-1]

Product Specifications

Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD86

Gene ID

12524

UniProt

P42082

Host

Rat

Reactivity

Mouse

Target

Activation B7-2 antigen; Cd86; ETC-1; Early T-cell costimulatory molecule 1; T-lymphocyte activation antigen CD86

Clonality

Monoclonal

Clone

GL-1

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

≥ 1 mg/mL

Dilution

66

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Product Datasheet

https://789.bio/ea/wtinvh

Product MSDS

https://789.bio/eb/1CWnrL

Citation 01

https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/advs.202414548

Citation 02

https://www.nature.com/articles/s12276-025-01465-6

Citation 03

https://link.springer.com/article/10.1186/s13046-025-03282-1

Citation 04

https://advanced.onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202500699

Citation 05

https://www.sciencedirect.com/science/article/pii/S1742706125000467

Citation 06

https://www.sciencedirect.com/science/article/pii/S0141813022028240

Citation 07

https://www.ijbs.com/v21p3081.htm

Citation 08

https://link.springer.com/article/10.1186/s12967-024-04931-3

Citation 09

https://www.sciencedirect.com/science/article/pii/S1756464624002196

Citation 10

https://www.tandfonline.com/doi/abs/10.1080/10826068.2024.2444979

Recommended Usage

6

Isotype

Rat IgG2a, κ

Available Sizes

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