Purified Anti-Mouse CD80 Antibody[16-10A1]

Product Specifications

Background

CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Abbreviation

CD80

Gene ID

12519

UniProt

Q00609

Host

Armenian Hamster

Reactivity

Mouse

Target

Activation B7-1 antigen; B7; Cd80; T-lymphocyte activation antigen CD80

Clonality

Monoclonal

Clone

16-10A1

Conjugation

Unconjugated

Applications

FCM

Field of Research

Cell Biology; Costimulatory Molecules; Immunology; Neuroscience; Neuroscience Cell Markers

Concentration

≥ 1 mg/mL

Buffer

Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Shipping Conditions

Ice bag

Storage Conditions

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Citation 01

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c12131

Citation 02

https://pubs.acs.org/doi/abs/10.1021/acsnano.4c18954

Citation 03

https://www.sciencedirect.com/science/article/pii/S0142961224004241

Citation 04

https://www.sciencedirect.com/science/article/pii/S1742706125000467

Citation 05

https://pubs.acs.org/doi/abs/10.1021/acsami.3c11227

Citation 06

https://www.sciencedirect.com/science/article/pii/S0141813022028240

Citation 07

https://www.sciencedirect.com/science/article/pii/S1818087622000587

Recommended Usage

Isotype

Armenian Hamster IgG

Available Sizes

Documents

Product Datasheet

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