DS21360717
DS21360717 is a potent and orally active FER tyrosine kinase inhibitor, with an IC50 of 0.49 nM. Anti-cancer activity[1].
Product Specifications
CAS Number
2304654-43-9
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ds21360717.html
Purity
99.80
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
N[C@H]1CCCC[C@H]1NC2=NC(NC3=CC(C)=CC=C3)=C4C(C=NNC4=O)=C2C#N
Molecular Formula
C21H23N7O
Molecular Weight
389.45
References & Citations
[1]Taniguchi T, et al. Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. ACS Med Chem Lett. 2019 Mar 15;10 (5) :737-742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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