Mavorixafor (hydrochloride)
Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively. Mavorixafor hydrochloride can be used for the study of WHIM syndrome[1].
Product Specifications
CAS Number
880549-30-4
Product Name Alternative
AMD-070 (hydrochloride) ; AMD-11070 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CXCR; HIV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/mavorixafor-hydrochloride.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCCCN(CC1=NC2=CC=CC=C2N1)[C@H]3CCCC4=C3N=CC=C4.[H]Cl
Molecular Formula
C21H28ClN5
Molecular Weight
385.93
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CXCR4; HIV-1
Available Sizes
Frequently Asked Questions
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