NPB
NPB is a specific and potent inhibitor of BAD phosphorylation at Ser99, with an IC50 of 0.41 μM[1].
Product Specifications
CAS Number
2247491-97-8
Product Name Alternative
Saponin
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/npb.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C(N2CCN(C3=C(Cl)C(Cl)=CC=C3)CC2)C4=CC=CC(C(NC5CCCC5)=O)=C4)C=CC=C1
Molecular Formula
C29H31Cl2N3O2
Molecular Weight
524.48
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Pandey V, et al. Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A. 2018 Oct 30;115 (44) :E10505-E10514.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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