A 922500

A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.

Product Specifications

CAS Number

[959122-11-3]

Product Name Alternative

DGAT-1 Inhibitor 4a

UNSPSC

12352005

Hazard Statement

H301, H319, H400, H410

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/A-922500.html

Purity

99.33

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NC1=CC=C(C2=CC=C(C([C@@H]3CCC[C@H]3C(O)=O)=O)C=C2)C=C1)NC4=CC=CC=C4

Molecular Formula

C26H24N2O4

Molecular Weight

428.48

Precautions

H301, H319, H400, H410

References & Citations

[1]King AJ, et al. Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. J Pharmacol Exp Ther. 2009 Aug;330 (2) :526-31.