Kainic acid
Product Specifications
UNSPSC Description
Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].
Target Antigen
EAAT
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Kainic_acid.html
Purity
99.96
Solubility
DMSO : 40 mg/mL (ultrasonic;adjust pH to 3 with 1 M HCL)|H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)=C
Molecular Weight
213.233
References & Citations
[1]Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28(14):903-909.|[2]Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31(1-3):3-16.|[3]Scherer-Singler U, McGeer EG. Distribution and persistence of kainic acid in brain. Life Sci. 1979 Mar 12;24(11):1015-22. |[4]Lévesque M, et al. The kainic acid model of temporal lobe epilepsy. Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2887-99.|[5]Zheng Z, et al. The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy. J Neuroinflammation. 2021 May 11;18(1):112. |[6]Chung SY, et al. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res. 2003 Mar;34(2):95-102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2309/Kainic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2309/Kainic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
487-79-6
Available Sizes
Curated Selection
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