Kainic acid

Kainic acid is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid induces seizures[1][2].

Product Specifications

CAS Number

[487-79-6]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

EAAT

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Kainic_acid.html

Purity

99.96

Solubility

DMSO : 40 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)=C

Molecular Formula

C10H15NO4

Molecular Weight

213.23

Precautions

H302, H312, H332

References & Citations

[1]Cincioğlu-Palabiyik M, et al. Chronic levetiracetam decreases hippocampal and testicular aromatase expression in normal but not kainic acid-induced experimental model of acute seizures in rats. Neuroreport. 2017 Sep 27;28 (14) :903-909.|[2]Wang Q, et al. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Mol Neurobiol. 2005;31 (1-3) :3-16.|[3]Scherer-Singler U, McGeer EG. Distribution and persistence of kainic acid in brain. Life Sci. 1979 Mar 12;24 (11) :1015-22. |[4]Lévesque M, et al. The kainic acid model of temporal lobe epilepsy. Neurosci Biobehav Rev. 2013 Dec;37 (10 Pt 2) :2887-99.|[5]Zheng Z, et al. The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy. J Neuroinflammation. 2021 May 11;18 (1) :112. |[6]Chung SY, et al. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res. 2003 Mar;34 (2) :95-102.