Amb123203
Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds[1].
Product Specifications
CAS Number
[956571-77-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/amb123203.html
Purity
98.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(CN1CCCC(C1)C2=NC3=C(S2)C=CC=C3)NC4=C(C)N(C5=CC=CC=C5)N=C4C
Molecular Formula
C25H27N5OS
Molecular Weight
445.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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