Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Regorafenib-13C, d3

Regorafenib-13C, d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively.

Product Specifications

Product Name Alternative

BAY 73-4506-13C, d3

UNSPSC

12352005

Target

Autophagy; PDGFR; Raf; RET; VEGFR

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O=C(N[13C]([2H])([2H])[2H])C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=C1

Molecular Formula

C20 13CH12D3ClF4N4O3

Molecular Weight

486.83

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Carr BI, et al. Fluoro-Bay 43-9006 (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228 (2), 292-297.|[3]Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2 (1), 39-49.|[4]Matsuoka K, et al. Effective Sequential Combined Chemotherapy with Tipiracil and Regorafenib in Human Colorectal Cancer Cells. Int J Mol Sci. 2018 Sep 25;19 (10) . pii: E2915.|[5]Wagner J, et al. Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms. J Exp Clin Cancer Res. 2018 Jan 22;37 (1) :11.|[6]Wilhelm SM, et al. Regorafenib (BAY 73-4506) : a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129 (1), 245-255.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Ferritin, Heavy Chain (FTH) (Microglia Marker) (FTH/2081), 0.2mg/mL
BNUB2081-100 1x 100 µL

Ferritin, Heavy Chain (FTH) (Microglia Marker) (FTH/2081), 0.2mg/mL

Sign In for Pricing
View Details
Mouse Pga5 activation kit by CRISPRa
GA206299 1 Kit

Mouse Pga5 activation kit by CRISPRa

Sign In for Pricing
View Details
CAMSAP1 (N-term) Rabbit Polyclonal Antibody
AP50720PU-N 400 µL

CAMSAP1 (N-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
(1S,3R)-3-Aminocyclohexanol Hydrochloride
TRC-A604455-250MG 250 mg

(1S,3R)-3-Aminocyclohexanol Hydrochloride

Sign In for Pricing
View Details
PKC epsilon (PRKCE) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3A12]
TA502540BM 100 µL

PKC epsilon (PRKCE) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3A12]

Sign In for Pricing
View Details
Pirin (PIR) Human Gene Knockout Kit (CRISPR)
KN200626 1 Kit

Pirin (PIR) Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details