S-22153
S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2].
Product Specifications
CAS Number
180304-07-8
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-22153.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NCCC1=CSC2=CC=C(C=C12)CC)=O
Molecular Formula
C14H17NOS
Molecular Weight
247.36
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1; MT2
Available Sizes
Frequently Asked Questions
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