Tricetin
Product Specifications
UNSPSC Description
Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1].
Target Antigen
Apoptosis; Keap1-Nrf2
Type
Natural Products
Related Pathways
Apoptosis;NF-κB
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tricetin.html
Purity
99.19
Solubility
DMSO : 25 mg/mL (ultrasonic;warming)
Smiles
O=C1C=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13
Molecular Weight
302.24
References & Citations
[1]Ren J, et al. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicol Appl Pharmacol. 2019;378:114617.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131592/Tricetin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131592/Tricetin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
520-31-0
Available Sizes
Curated Selection
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