Tricetin

Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI) . Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway[1].

Product Specifications

CAS Number

[520-31-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Keap1-Nrf2

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tricetin.html

Purity

99.19

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H10O7

Molecular Weight

302.24

Precautions

H315, H319, H335

References & Citations

[1]Ren J, et al. Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Toxicol Appl Pharmacol. 2019;378:114617.