Seconeolitsine

Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA) . Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics[1].

Product Specifications

CAS Number

[2650074-56-7]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Topoisomerase

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/seconeolitsine.html

Purity

98.65

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1

Molecular Formula

C19H17NO4

Molecular Weight

323.34

References & Citations

[1]María Teresa García, et al. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumonia. J Biol Chem. 2011 Feb 25;286 (8) :6402-13.