Seconeolitsine
Product Specifications
UNSPSC Description
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics[1].
Target Antigen
Antibiotic; Bacterial; Topoisomerase
Type
Natural Products
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/seconeolitsine.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CNCCC1=C2C=CC3=CC(OCO4)=C4C=C3C2=C5OCOC5=C1
Molecular Weight
323.34
References & Citations
[1]María Teresa García, et al. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumonia. J Biol Chem. 2011 Feb 25;286(8):6402-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10495/Seconeolitsine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10495/Seconeolitsine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2650074-56-7
Available Sizes
Curated Selection
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