Endosidin-2

Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation) . Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) [1][2].

Product Specifications

CAS Number

[1839524-44-5]

Product Name Alternative

ES2

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/endosidin-2.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N/N=C/C1=CC(OC)=C(O)C(I)=C1)C2=CC=CC(F)=C2

Molecular Formula

C15H12FIN2O3

Molecular Weight

414.17

Precautions

H315, H319

References & Citations

[1]Zhang C, et al. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. 2016 Jan 5;113 (1) :E41-50.|[2]Lešková A, et al. Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1. PLoS One. 2020 Aug 13;15 (8) :e0237448.