Phenacaine
Phenacaine (Holocaine) is a local agent that can suppress or relieve pain. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart[1][2].
Product Specifications
CAS Number
[101-93-9]
Product Name Alternative
Holocaine
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/phenacaine.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(NC1=CC=C(OCC)C=C1)=N\C2=CC=C(OCC)C=C2
Molecular Formula
C18H22N2O2
Molecular Weight
298.38
References & Citations
[1]M Volpi, et al. Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin. Proc Natl Acad Sci U S A. 1981 Feb;78 (2) :795-9. |[2]R Bressler, et al. Effect of local anesthetics on insulin secretion by pancreas pieces. Diabetes. 1971 Nov;20 (11) :721-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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