Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TNFRSF11B/OPG, Human (HEK293, His, solution)

Osteoprotegerin (OPG), a TNF receptor superfamily, is expressed in many tissues including heart, kidney, liver, spleen, and bone marrow. Osteoprotegerin has osteoprotective effect and is critical in bone remodeling. Osteoprotegerin can bind to RANKL and inhibit the binding between TNFSF11 and RANKL, thereby neutralizing the RANKL function in osteoclastogenesis[1]. OPG is also involved in multiple biological processes of cancers. TNFRSF11B/OPG Protein, Human (HEK293, His, solution) is a recombinant human TNFRSF11B/OPG (E22-L401) with C-terminal His tag, which is produced in HEK293 cell[1][2].

Product Specifications

Product Name Alternative

TNFRSF11B/OPG Protein, Human (HEK293, His, solution), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/tnfrsf11b-opg-protein-human-401a-a-hek293-his.html

Purity

97.40

Molecular Formula

4982 (Gene_ID) O00300 (E22-L401) (Accession)

Molecular Weight

Approximately 58 kDa

References & Citations

[1]Boyce BF, et al. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 2007;9 Suppl 1 (Suppl 1) :S1.|[2]Wang Y, et al. The roles of osteoprotegerin in cancer, far beyond a bone player. Cell Death Discov. 2022 May 6;8 (1) :252.|[3]Venuraju SM, et al. Osteoprotegerin as a predictor of coronary artery disease and cardiovascular mortality and morbidity. J Am Coll Cardiol. 2010 May 11;55 (19) :2049-61.|[4]Capparelli C, et al. Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG) : a pharmacodynamic and pharmacokinetic analysis in rats. J Bone Miner Res. 2003 May;18 (5) :852-8.|[5]Candido R, et al. Human full-length osteoprotegerin induces the proliferation of rodent vascular smooth muscle cells both in vitro and in vivo. J Vasc Res. 2010;47 (3) :252-61.

Shipping Conditions

Dry ice.

Storage Conditions

Stored at -80°C for 1 year

Scientific Category

Recombinant Proteins

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Histone H1 (Pan Nuclear Marker) (N/A), CF740 conjugate, 0.1mg/mL
BNC741816-100 1x 100 µL

Histone H1 (Pan Nuclear Marker) (N/A), CF740 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Benz[a]anthracene-7-acetic Acid-13C2
TRC-B183572-5MG 5 mg

Benz[a]anthracene-7-acetic Acid-13C2

Sign In for Pricing
View Details
Wnt5b Mouse Gene Knockout Kit (CRISPR)
KN519456 1 Kit

Wnt5b Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Sonic Hedgehog (SHH) (N-term) Rabbit Polyclonal Antibody
AP23351PU-N 100 µg

Sonic Hedgehog (SHH) (N-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
EGFR (Epidermal Growth Factor Receptor) (GFR/2341), Biotin conjugate, 0.1mg/mL
BNCB2341-100 1x 100 µL

EGFR (Epidermal Growth Factor Receptor) (GFR/2341), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
BSDC1 Antibody
KC-42518-01 50 μL

BSDC1 Antibody

Sign In for Pricing
View Details