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Human GSK-3beta / GSK-3β Protein, His Tag (active enzyme, HPLC verified)

Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD) . GSK-3beta is involved in the formation of paired helical filament (PHF) -tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.

Product Specifications

Background

Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of Alzheimer's disease (AD) . GSK-3beta is involved in the formation of paired helical filament (PHF) -tau, which is an integral component of the neurofibrillary tangle (NFT) deposits that disrupt neuronal function, and a marker of neurodegeneration in AD.

Specifications

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 48.8 kDa. The protein migrates as 49-53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P49841-1

Expression Region

Met 1 - Thr 420

Host

Insect Cells

Target

GSK-3beta

Conjugation

Unconjugated

Tag

N-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Purity

90%

Format

Liquid

Buffer

50 mM Tris, 150 mM NaCl, pH7.5

Additives

Glycerol

Molecular Weight

48.8 kDa

Additionnal Information

Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments

Shipping Conditions

Dry ice

Storage Conditions

-70°C

Package Size

500ug*1

Host or Source

InsectCells

Species

Human

Protein ID

P49841-1

Preservative

Glycerol

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